Zogulitsa

Zogulitsa za PO zimakhala ndi anti-dandruff komanso anti-kuyabwa, makina apadera odana ndi dandruff, kusungunuka kwabwino komanso kuphatikizanso, chitetezo, chosakhala ndi poizoni, chosakwiyitsa, ndipo amagwiritsidwa ntchito makamaka mu shampoo ndi mankhwala osamalira tsitsi.PO ili ndi zotsatira zabwino kwambiri za antipruritic, komanso imakhala ndi ntchito zoletsa komanso zochotsa fungo, motero imagwiritsidwa ntchito posamba mafuta osambira kuti ikwaniritse zotsatira zabwino.PO imapha kwambiri mafangasi ndi nkhungu, ndipo imakhala ndi chithandizo chabwino pamapazi ndi zipere zamanja.Itha kugwiritsidwa ntchito ngati chosungira mu zodzoladzola, monga bactericide mu sopo, komanso ngati thickening wothandizira.Chifukwa chake, PO ndi anti-dandruff ndi antipruritic bactericide, yomwe imagwiritsidwa ntchito kwambiri popanga shampoo ndi zosamalira tsitsi, mafuta osambira, zodzoladzola, ndi zotsukira.

Piroctone olamine, mchere wa ethanolamine wa hydroxamic acid wochokera ku Piroctone, ndi hydroxypyridone anti-mycotic agent.Piroctone olamine imalowa mu membrane ya cell ndikupanga ma complexes okhala ndi ayoni achitsulo, kuletsa mphamvu ya metabolism mu mitochondria[1].Piroctone olamine (PO) ndi mchere wa ethanolamine wa hydroxamic acid wochokera ku Piroctone.Mitundu yonse ya Candida imawonetsa kutsika kochepa kwambiri kwa inhibitory concentrations (MICs) kwa Piroctone olamine (0.125-0.5 μg/mL) ndi Amphotericin B (AMB) (0.03-1 μg/mL).

Ntchitoyi ikufuna kuyesa ntchito ya antifungal ya Piroctone olamine pochiza candidiasis m'mimba mwachitsanzo choyesera pogwiritsa ntchito mbewa za ku Swiss.Chithandizo ndi Piroctone olamine (0.5 mg/kg) ikuchitika 72 h pambuyo matenda ndi intraperitoneal makonzedwe.Poyerekeza, gulu la nyama (n=6) limathandizidwa ndi Amphotericin B (0.5 mg/kg).Kuzindikira kwa mycological kumachitika posonkhanitsa chiwindi, ndulu ndi impso.Zambiri zokhudzana ndi kukula kwa mafangasi ndi kufa zimawunikidwa mowerengera ndi mayeso a Wophunzira ndikuwunika kusiyanasiyana, ndi mulingo wofunikira wokhazikitsidwa pa P.<0.05.Kusiyana kwa kukula kwa mafangasi pakati pa gulu lolamulira ndi magulu ochiritsira (Piroctone olamine ndi Amphotericin B) ndikofunika kwambiri (P<0.05)